From: Oleic acid based experimental evolution of Bacillus megaterium yielding an enhanced P450 BM3 variant
Organism | p450 Cytochrome | Mutations towards consensus | Mutations leaving consensus | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A28T | V470E | T664A | T715A | A741G | E887G | M967V | A1008D | D1019E | Q546E | K639A | D893G | E947K | ||
Bacillus megaterium | CYP102A1 WT | A | V | T | T | A | E | M | A | D | Q | K | D | E |
 | CYP102A1 DE | T | E | A | A | G | G | V | D | E | E | A | G | K |
Bacillus subtilis | CYP102A2 | S | Q | A | L | G | R | K | D | A | Q | K | D | D |
 | CYP102A3 | S | A | G | L | D | G | V | D | A | G |  | D | E |
Bacillus anthracis | CYP102A4 | S | E | A | L | D | N | L | D | E | Q | K | N | T |
Bacillus cereus | CYP102A5 | S | E | A | L | D | N | L | D | E | Q | K | D | T |
Bradyrhizobium diazoefficiens | CYP102A6 | H | R | M | A | G | G | A | D | E | Q | A | D | D |
Bacillus licheniformis | CYP102A7 | S | G | A | F | E | G | L | A | I | E | T | D | D |
Bacillus thuringiensis | CYP102A8 | S | E | A | L | D | N | L | D | E | Q | K | N | T |
Bacillus weihenstephanensis | CYP102A9 | S | E | A | L | D | N | L | D | E | Q | K | N | T |
Streptomyces avermitilis | CYP102D1 | Y | Q | L | L | G | T | V | A | K | R | P | D | Q |
Actinosynnema pretiosum | CYP102F1 | F | V | A | V | G | S | H | A | Â | H | R | D | E |
Consensus | PUsc, S/T | E | A | Hsc, A/L | G | G | Hsc | D | E | Q | K | D | NCsc | Â |
Secondary consensus | Â | Â | Â | Â | NCsc | Hsc | Â | Â | Â | Â | Â | Â | Â | Â |