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  1. Quantitative analysis of differential gene expression is of central importance in molecular life sciences. The Gene eXpression Profiling technology (GeXP) relies on multiplex RT-PCR and subsequent capillary el...

    Authors: Pauline Marquardt, Britta Werthmann, Viktoria Rätzel, Markus Haas and Wolfgang Marwan

    Citation: BMC Biotechnology 2021 21:29

    Content type: Methodology article

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  2. Microbial polysaccharides have been reported to possess remarkable bioactivities. Physarum polycephalum is a species of slime mold for which the microplasmodia are capable of rapid growth and can produce a signif...

    Authors: Tuyen T. H. Do, Tran N. B. Lai, Steven L. Stephenson and Hanh T. M. Tran

    Citation: BMC Biotechnology 2021 21:28

    Content type: Research article

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  3. Phakopsora pachyrhizi is a biotrophic fungal pathogen responsible for the Asian soybean rust disease causing important yield losses in tropical and subtropical soybean-producing countries. P. pachyrhizi triggers ...

    Authors: L. Cabre, S. Peyrard, C. Sirven, L. Gilles, B. Pelissier, S. Ducerf and N. Poussereau

    Citation: BMC Biotechnology 2021 21:27

    Content type: Research article

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  4. The production of agricultural wastes still growing as a consequence of the population growing. However, the majority of these residues are under-utilized due their chemical composition, which is mainly compos...

    Authors: Martha María Arevalos-Sánchez, Adrián Omar Maynez-Perez, Felipe A. Rodríguez-Almeida, José Alfredo Martínez-Quintana, Fidel Alejandro Sanchez-Flores, Monserrath Felix-Portillo, América Chavéz-Martínez, Myrna Elena Olvera-García, Oscar Ruiz-Barrera and Agustín Corral-Luna

    Citation: BMC Biotechnology 2021 21:26

    Content type: Research article

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  7. Ogataea polymorpha is a thermotolerant, methylotrophic yeast with significant industrial applications. While previously mainly used for protein synthesis, it also holds promise for producing platform chemicals. O...

    Authors: Ulf W Liebal, Brigida A Fabry, Aarthi Ravikrishnan, Constantin VL Schedel, Simone Schmitz, Lars M Blank and Birgitta E Ebert

    Citation: BMC Biotechnology 2021 21:23

    Content type: Research article

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  8. The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify t...

    Authors: Masoumeh Adhami, Balal Sadeghi, Ali Rezapour, Ali Akbar Haghdoost and Habib MotieGhader

    Citation: BMC Biotechnology 2021 21:22

    Content type: Research article

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  9. Proteases are important for hydrolysis of proteins to generate peptides with many bioactivities. Thus, the development of novel proteases with high activities is meaningful to discover bioactive peptides. Beca...

    Authors: Chang Chang, Siyi Gong, Zhiping Liu, Qiaojuan Yan and Zhengqiang Jiang

    Citation: BMC Biotechnology 2021 21:21

    Content type: Research article

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  10. Over the past decade, therapeutic messenger RNAs (mRNAs) have emerged as a highly promising new class of drugs for protein replacement therapies. Due to the recent developments, the incorporation of modified n...

    Authors: Cynthia Aslan, Seyed Hossein Kiaie, Naime Majidi Zolbanin, Parisa Lotfinejad, Reihaneh Ramezani, Fatah Kashanchi and Reza Jafari

    Citation: BMC Biotechnology 2021 21:20

    Content type: Review

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  12. Aldehyde dehydrogenases are vital for aerobic hydrocarbon degradation and is involved in the last step of catalysing the oxidation of aldehydes to carboxylic acids. With the global increase in hydrocarbon poll...

    Authors: Cindy Baburam and Naser Aliye Feto

    Citation: BMC Biotechnology 2021 21:18

    Content type: Research article

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  13. Alanine decarboxylase (AlaDC), specifically present in tea plants, is crucial for theanine biosynthesis. Serine decarboxylase (SDC), found in many plants, is a protein most closely related to AlaDC. To investi...

    Authors: Peixian Bai, Liyuan Wang, Kang Wei, Li Ruan, Liyun Wu, Mengdi He, Dejiang Ni and Hao Cheng

    Citation: BMC Biotechnology 2021 21:17

    Content type: Research article

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  14. A plant growth-promoting endophytic bacterium PVL1 isolated from the leaf of Vanda cristata has the ability to colonize with roots of plants and protect the plant. PVL1 was isolated using laboratory synthetic ...

    Authors: Sujit Shah, Krishna Chand, Bhagwan Rekadwad, Yogesh S. Shouche, Jyotsna Sharma and Bijaya Pant

    Citation: BMC Biotechnology 2021 21:16

    Content type: Research article

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  15. CRISPR-Cas genome editing technologies have revolutionized biotechnological research particularly in functional genomics and synthetic biology. As an alternative to the most studied and well-developed CRISPR/C...

    Authors: Dede Abdulrachman, Lily Eurwilaichitr, Verawat Champreda, Duriya Chantasingh and Kusol Pootanakit

    Citation: BMC Biotechnology 2021 21:15

    Content type: Research article

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  16. Levan is a well-known homopolymer of fructose composed predominantly of β-(2, 6) fructofuranosyl linkages in the backbone with occasional β-(2, 1) linkages in the branch chains with varied applications. Howeve...

    Authors: Jin Han, Huafeng Feng, Xiaohua Wang, Zhenmin Liu and Zhengjun Wu

    Citation: BMC Biotechnology 2021 21:14

    Content type: Research article

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  18. Lyso-phosphatidylethanolamine (LPE) is a natural phospholipid that functions in the early stages of plant senescence. Plant innate immunity and early leaf senescence share molecular components. To reveal conserve...

    Authors: Ronny Völz, Ju-Young Park, William Harris, Sungkee Hwang and Yong-Hwan Lee

    Citation: BMC Biotechnology 2021 21:12

    Content type: Research article

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  19. Human epithelial cell sheets (ECSs) are used to clinically treat epithelial conditions such as burns, corneal blindness, middle ear cholesteatoma and vitiligo. As a widely used material in clinic, there is lit...

    Authors: Dongliang Zhang, Jialiang Shao, Jingming Zhuang, Shukui Zhou, Shuo Yin, Fuyue Wu, Jiangang Hou and Xiang Wang

    Citation: BMC Biotechnology 2021 21:11

    Content type: Research article

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  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee

    Citation: BMC Biotechnology 2021 21:10

    Content type: Correction

    Published on:

    The original article was published in BMC Biotechnology 2021 21:1

  21. The ability of CRISPR/Cas9 to mutate any desired genomic locus is being increasingly explored in the emerging area of cancer immunotherapy. In this respect, current efforts are mostly focused on the use of aut...

    Authors: Elahe Kamali, Fatemeh Rahbarizadeh, Zohreh Hojati and Morten Frödin

    Citation: BMC Biotechnology 2021 21:9

    Content type: Research article

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  22. Nowadays, the number of cancer survivors is significantly increasing as a result of efficient chemo/radio therapeutic treatments. Female cancer survivors may suffer from decreased fertility. In this regard, di...

    Authors: Hossein Nikniaz, Zahra Zandieh, Mohammad Nouri, Neda Daei-farshbaf, Reza Aflatoonian, Mazaher Gholipourmalekabadi and Seyed Behnamedin Jameie

    Citation: BMC Biotechnology 2021 21:8

    Content type: Research article

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  23. Bacterial degradation/transformation of steroids is widely investigated to create biotechnologically relevant strains for industrial application. The strain of Nocardioides simplex VKM Ac-2033D is well known main...

    Authors: Victoria Yu Shtratnikova, Mikhail I. Sсhelkunov, Victoria V. Fokina, Eugeny Y. Bragin, Andrey A. Shutov and Marina V. Donova

    Citation: BMC Biotechnology 2021 21:7

    Content type: Research article

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  24. Microcapsule is considered as a promising 3D microenvironment for Bone Tissue Engineering (BTE) applications. Microencapsulation of cells in an appropriate scaffold not only protected the cells against excess ...

    Authors: Mahdieh Alipour, Nima Firouzi, Zahra Aghazadeh, Mohammad Samiei, Soheila Montazersaheb, Ali Baradar Khoshfetrat and Marziyeh Aghazadeh

    Citation: BMC Biotechnology 2021 21:6

    Content type: Research article

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  26. As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productiv...

    Authors: Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock, Dwon Jordana, Zhigang Li, Cathy Wu, Sarah W. Harcum and Christopher A. Saski

    Citation: BMC Biotechnology 2021 21:4

    Content type: Research article

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  28. The initial step of influenza infection is binding of the virus to specific sialic acid receptors expressed by host cells. This is followed by cell entry via endocytosis. Cleavage of the influenza virus hemagg...

    Authors: Kelly Chungu, Young Hyun Park, Seung Je Woo, Su Bin Lee, Deivendran Rengaraj, Hong Jo Lee and Jae Yong Han

    Citation: BMC Biotechnology 2021 21:2

    Content type: Research article

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  29. Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals su...

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee

    Citation: BMC Biotechnology 2021 21:1

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Biotechnology 2021 21:10

  30. Chicken feathers are the most abundant agro-wastes emanating from the poultry processing farms and present major concerns to environmentalists. Bioutilization of intractable feather wastes for the production o...

    Authors: Nonso E. Nnolim and Uchechukwu U. Nwodo

    Citation: BMC Biotechnology 2020 20:65

    Content type: Research article

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  31. Lignin in sugarcane bagasse (SB) hinders its utilization by microorganism, therefore, pretreatment methods are employed to make fermentable components accessible to the microbes. Multivariate analysis of diffe...

    Authors: Rozina Rashid, Uroosa Ejaz, Firdous Imran Ali, Imran Ali Hashmi, Ahmed Bari, Jing Liu, Li Wang, Pengcheng Fu and Muhammad Sohail

    Citation: BMC Biotechnology 2020 20:64

    Content type: Research article

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  32. As a main drug for diseased thrombus, some clinically used thrombolytic agents have various disadvantages, safer novel thrombolytic agents are of great demand. This study aimed to achieve high and efficient pr...

    Authors: Zhiqun Che, Xiaoyan Cao, Guiguang Chen and Zhiqun Liang

    Citation: BMC Biotechnology 2020 20:63

    Content type: Research article

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  33. Elaboration of the epigenetic regulation of chromatin is a long-standing aim in molecular and cellular biology. Hence, there is a great demand for the development of in vitro methods to reconstitute chromatin ...

    Authors: Kei-ichi Okimune, Szilvia K. Nagy, Shogo Hataya, Yaeta Endo and Taichi E. Takasuka

    Citation: BMC Biotechnology 2020 20:62

    Content type: Methodology article

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  34. Harmful cyanobacterial blooms have attracted wide attention all over the world as they cause water quality deterioration and ecosystem health issues. Microcystis aeruginosa associated with a large number of bacte...

    Authors: Suqin Gao, Yun Kong, Jing Yu, Lihong Miao, Lipeng Ji, Lirong Song and Chi Zeng

    Citation: BMC Biotechnology 2020 20:61

    Content type: Research article

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  35. Moringa stenopetala belongs to the flowering family Moringaceae and genus Moringa. It is often referred to as the East African Moringa tree because it is native only to southern Ethiopia and northern Kenya. The e...

    Authors: Alelegne Yeshamebel Adugna, Tileye Feyissa and Fikresilasie Samuel Tasew

    Citation: BMC Biotechnology 2020 20:60

    Content type: Research article

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  36. Equine chorionic gonadotropin (eCG) induces super-ovulation in laboratory animals. Notwithstanding its extensive usage, limited information is available regarding the differences between the in vivo effects of...

    Authors: Kwan-Sik Min, Jong-Ju Park, So-Yun Lee, Munkhzaya Byambaragchaa and Myung-Hwa Kang

    Citation: BMC Biotechnology 2020 20:59

    Content type: Research article

    Published on:

  37. Development of precise genome editing strategies is a prerequisite for producing edited plants that can aid in the study of gene function and help understand the genetic traits in a cultivar. Citrus embryogeni...

    Authors: Manjul Dutt, Zhonglin Mou, Xudong Zhang, Sameena E. Tanwir and Jude W. Grosser

    Citation: BMC Biotechnology 2020 20:58

    Content type: Research article

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  38. Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR)....

    Authors: Sanum Bashir, Tu Dang, Jana Rossius, Johanna Wolf and Ralf Kühn

    Citation: BMC Biotechnology 2020 20:57

    Content type: Research article

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  39. Lignocellulosic biomass, is a great resource for the production of bio-energy and bio-based material since it is largely abundant, inexpensive and renewable. The requirement of new energy sources has led to a ...

    Authors: Shohreh Ariaeenejad, Atefeh Sheykh Abdollahzadeh Mamaghani, Morteza Maleki, Kaveh Kavousi, Mehdi Foroozandeh Shahraki and Ghasem Hosseini Salekdeh

    Citation: BMC Biotechnology 2020 20:56

    Content type: Research article

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  40. Buriti oil presents numerous health benefits, but due to its lipophilic nature and high oxidation, it is impossible to incorporate it into aqueous food matrices. Thus, the present study evaluated whether powde...

    Authors: Gabrielle Mahara Martins Azevedo Castro, Thais Souza Passos, Sara Sayonara da Cruz Nascimento, Isaiane Medeiros, Nathália Kelly Araújo, Bruna Leal Lima Maciel, Carlos Eduardo Padilha, Adriana Margarida Zanbotto Ramalho, Francisco Canidé Sousa Júnior and Cristiane Fernandes de Assis

    Citation: BMC Biotechnology 2020 20:55

    Content type: Research article

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  41. Gene doctoring is an efficient recombination-based genetic engineering approach to mutagenesis of the bacterial chromosome that combines the λ-Red recombination system with a suicide donor plasmid that is clea...

    Authors: Nicholas M. Thomson, Chuanzhen Zhang, Eleftheria Trampari and Mark J. Pallen

    Citation: BMC Biotechnology 2020 20:54

    Content type: Research article

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  42. Few bead-based multiplex assays have been described that detect antibodies against the protozoan parasite Toxoplasma gondii in large-scale seroepidemiological surveys. Moreover, each multiplex assay has specific ...

    Authors: Sandra Klein, Daniel Stern and Frank Seeber

    Citation: BMC Biotechnology 2020 20:53

    Content type: Methodology article

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  43. Obesity and its related diseases are increasing worldwide. One of the best therapeutic strategies for obesity management is through the inhibition of pancreatic lipase (PL) enzyme. So far orlistat is the only ...

    Authors: Sarah Mohamed El-Korany, Omneya Mohamed Helmy, Ali Mahmoud El-Halawany, Yasser El-Mohammadi Ragab and Hamdallah Hafez Zedan

    Citation: BMC Biotechnology 2020 20:52

    Content type: Research article

    Published on:

  44. Cassava is a staple food for over 800 million people globally providing a cheap source of carbohydrate. However, the cultivation of cassava in the country is facing to viral diseases, particularly cassava mosa...

    Authors: Amitchihoué Franck Sessou, Jane W. Kahia, Jerome Anani Houngue, Elijah Miinda Ateka, Colombe Dadjo and Corneille Ahanhanzo

    Citation: BMC Biotechnology 2020 20:51

    Content type: Research article

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  45. Pelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented use of an aqueous-ethanolic formulation of the roots of P. sidoides (EPs 76...

    Authors: V. Lukman, S. W. Odeyemi, R. L. Roth, L. Mbabala, N. Tshililo, N. M. Vlok, M. J. B. Dewar and C. P. Kenyon

    Citation: BMC Biotechnology 2020 20:50

    Content type: Research article

    Published on:

  47. Human TGF-β3 has been used in many studies to induce genes coding for typical cartilage matrix components and accelerate chondrogenic differentiation, making it the standard constituent in most cultivation media ...

    Authors: Yijiang Huang, Daniel Seitz, Yan Chevalier, Peter E. Müller, Volkmar Jansson and Roland M. Klar

    Citation: BMC Biotechnology 2020 20:48

    Content type: Research article

    Published on:

  48. Approximately 40% of prescribed drugs exert their activity via GTP-binding protein-coupled receptors (GPCRs). Once activated, these receptors cause transient changes in the concentration of second messengers, ...

    Authors: Nadine Gruteser, Viktoria Kohlhas, Sabine Balfanz, Arne Franzen, Anne Günther, Andreas Offenhäusser, Frank Müller, Viacheslav Nikolaev, Martin J. Lohse and Arnd Baumann

    Citation: BMC Biotechnology 2020 20:47

    Content type: Methodology article

    Published on:

  50. Vitrification is the most promising technology for successful cryopreservation of living organisms without ice crystal formation. However, high concentrations (up to ~ 6–8 M) of cryoprotective agents (CPAs) us...

    Authors: Young-Hoon Jeong, Ukjin Kim, Seul-Gi Lee, Bokyeong Ryu, Jin Kim, Artyuhov Igor, Jong Soo Kim, Cho-Rok Jung, Jae-Hak Park and C-Yoon Kim

    Citation: BMC Biotechnology 2020 20:45

    Content type: Research article

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