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Fig. 5 | BMC Biotechnology

Fig. 5

From: Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics

Fig. 5

Blood pressure control and in vivo Hb:Hp complex formation. a Guinea pigs (n = 4 per group) were infused with 25 mg of Hb at time 0 min. At t = 5 min, when mean arterial blood pressure (MAP) reached a maximum increase rHp (25 mg) was injected. Separate groups were treated with rHp1S (left) and rHp2FS (right). Data show mean ± SD. Values were compared with an ANOVA for repeated measures and a Tukey post-hoc test correction for multiple comparisons. b Plasma samples collected at baseline, 5 min post Hb infusion and 5, 30 and 60 min post rHp injection were analyzed by HPLC size-exclusion chromatography. The red area indicates the elution profile of a cell-free Hb standard, the blue area indicates the elution profile of the respective Hb:Hp complexes with rHp1S and rHp2FS

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BMC Biotechnology

ISSN: 1472-6750

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