Fig. 12
Effect of IFN α2b, IFN-CSP on HBV core protein in the liver of HBV-transgenic mice. a normal non-transgenic mice control; (b) physiological saline control; (c) IFN α2b, 103 U/g body weight; (d) IFN-CSP, 101 U/g body weight; (e) IFN-CSP, 102 U/g body weight; (f) IFN-CSP, 103 U/g body weight. The treatment continued for 28 days, liver of mice were collected for analyses. a: Representative photographs of liver sections immunofluorescent stained with anti-HBcAg antibody are presented. Arrows indicate distinct green fluorescent labeling of HBcAg in liver, blue nuclear stained with DAPI. Calibration bar =50 μm for photomicrographs. b: The core protein was also quantified by western blot analysis. c: Optical densities of the core protein were analyzed using Quantity One software. The data are the mean ± SEM from six mice. *P < 0.05 vs physiological saline controls, **P < 0.01 vs physiological saline controls, # # P < 0.01 vs IFN α2b controls