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  1. A plant growth-promoting endophytic bacterium PVL1 isolated from the leaf of Vanda cristata has the ability to colonize with roots of plants and protect the plant. PVL1 was isolated using laboratory synthetic ...

    Authors: Sujit Shah, Krishna Chand, Bhagwan Rekadwad, Yogesh S. Shouche, Jyotsna Sharma and Bijaya Pant

    Citation: BMC Biotechnology 2021 21:16

    Content type: Research article

    Published on:

  2. CRISPR-Cas genome editing technologies have revolutionized biotechnological research particularly in functional genomics and synthetic biology. As an alternative to the most studied and well-developed CRISPR/C...

    Authors: Dede Abdulrachman, Lily Eurwilaichitr, Verawat Champreda, Duriya Chantasingh and Kusol Pootanakit

    Citation: BMC Biotechnology 2021 21:15

    Content type: Research article

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  3. Levan is a well-known homopolymer of fructose composed predominantly of β-(2, 6) fructofuranosyl linkages in the backbone with occasional β-(2, 1) linkages in the branch chains with varied applications. Howeve...

    Authors: Jin Han, Huafeng Feng, Xiaohua Wang, Zhenmin Liu and Zhengjun Wu

    Citation: BMC Biotechnology 2021 21:14

    Content type: Research article

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  4. Lyso-phosphatidylethanolamine (LPE) is a natural phospholipid that functions in the early stages of plant senescence. Plant innate immunity and early leaf senescence share molecular components. To reveal conserve...

    Authors: Ronny Völz, Ju-Young Park, William Harris, Sungkee Hwang and Yong-Hwan Lee

    Citation: BMC Biotechnology 2021 21:12

    Content type: Research article

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  5. Human epithelial cell sheets (ECSs) are used to clinically treat epithelial conditions such as burns, corneal blindness, middle ear cholesteatoma and vitiligo. As a widely used material in clinic, there is lit...

    Authors: Dongliang Zhang, Jialiang Shao, Jingming Zhuang, Shukui Zhou, Shuo Yin, Fuyue Wu, Jiangang Hou and Xiang Wang

    Citation: BMC Biotechnology 2021 21:11

    Content type: Research article

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee

    Citation: BMC Biotechnology 2021 21:10

    Content type: Correction

    Published on:

    The original article was published in BMC Biotechnology 2021 21:1

  7. The ability of CRISPR/Cas9 to mutate any desired genomic locus is being increasingly explored in the emerging area of cancer immunotherapy. In this respect, current efforts are mostly focused on the use of aut...

    Authors: Elahe Kamali, Fatemeh Rahbarizadeh, Zohreh Hojati and Morten Frödin

    Citation: BMC Biotechnology 2021 21:9

    Content type: Research article

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  8. Nowadays, the number of cancer survivors is significantly increasing as a result of efficient chemo/radio therapeutic treatments. Female cancer survivors may suffer from decreased fertility. In this regard, di...

    Authors: Hossein Nikniaz, Zahra Zandieh, Mohammad Nouri, Neda Daei-farshbaf, Reza Aflatoonian, Mazaher Gholipourmalekabadi and Seyed Behnamedin Jameie

    Citation: BMC Biotechnology 2021 21:8

    Content type: Research article

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  9. Bacterial degradation/transformation of steroids is widely investigated to create biotechnologically relevant strains for industrial application. The strain of Nocardioides simplex VKM Ac-2033D is well known main...

    Authors: Victoria Yu Shtratnikova, Mikhail I. Sсhelkunov, Victoria V. Fokina, Eugeny Y. Bragin, Andrey A. Shutov and Marina V. Donova

    Citation: BMC Biotechnology 2021 21:7

    Content type: Research article

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  10. Microcapsule is considered as a promising 3D microenvironment for Bone Tissue Engineering (BTE) applications. Microencapsulation of cells in an appropriate scaffold not only protected the cells against excess ...

    Authors: Mahdieh Alipour, Nima Firouzi, Zahra Aghazadeh, Mohammad Samiei, Soheila Montazersaheb, Ali Baradar Khoshfetrat and Marziyeh Aghazadeh

    Citation: BMC Biotechnology 2021 21:6

    Content type: Research article

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  11. As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productiv...

    Authors: Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock, Dwon Jordana, Zhigang Li, Cathy Wu, Sarah W. Harcum and Christopher A. Saski

    Citation: BMC Biotechnology 2021 21:4

    Content type: Research article

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  12. The initial step of influenza infection is binding of the virus to specific sialic acid receptors expressed by host cells. This is followed by cell entry via endocytosis. Cleavage of the influenza virus hemagg...

    Authors: Kelly Chungu, Young Hyun Park, Seung Je Woo, Su Bin Lee, Deivendran Rengaraj, Hong Jo Lee and Jae Yong Han

    Citation: BMC Biotechnology 2021 21:2

    Content type: Research article

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  13. Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals su...

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee

    Citation: BMC Biotechnology 2021 21:1

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Biotechnology 2021 21:10

  14. Chicken feathers are the most abundant agro-wastes emanating from the poultry processing farms and present major concerns to environmentalists. Bioutilization of intractable feather wastes for the production o...

    Authors: Nonso E. Nnolim and Uchechukwu U. Nwodo

    Citation: BMC Biotechnology 2020 20:65

    Content type: Research article

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  15. Lignin in sugarcane bagasse (SB) hinders its utilization by microorganism, therefore, pretreatment methods are employed to make fermentable components accessible to the microbes. Multivariate analysis of diffe...

    Authors: Rozina Rashid, Uroosa Ejaz, Firdous Imran Ali, Imran Ali Hashmi, Ahmed Bari, Jing Liu, Li Wang, Pengcheng Fu and Muhammad Sohail

    Citation: BMC Biotechnology 2020 20:64

    Content type: Research article

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  16. As a main drug for diseased thrombus, some clinically used thrombolytic agents have various disadvantages, safer novel thrombolytic agents are of great demand. This study aimed to achieve high and efficient pr...

    Authors: Zhiqun Che, Xiaoyan Cao, Guiguang Chen and Zhiqun Liang

    Citation: BMC Biotechnology 2020 20:63

    Content type: Research article

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  17. Elaboration of the epigenetic regulation of chromatin is a long-standing aim in molecular and cellular biology. Hence, there is a great demand for the development of in vitro methods to reconstitute chromatin ...

    Authors: Kei-ichi Okimune, Szilvia K. Nagy, Shogo Hataya, Yaeta Endo and Taichi E. Takasuka

    Citation: BMC Biotechnology 2020 20:62

    Content type: Methodology article

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  18. Harmful cyanobacterial blooms have attracted wide attention all over the world as they cause water quality deterioration and ecosystem health issues. Microcystis aeruginosa associated with a large number of bacte...

    Authors: Suqin Gao, Yun Kong, Jing Yu, Lihong Miao, Lipeng Ji, Lirong Song and Chi Zeng

    Citation: BMC Biotechnology 2020 20:61

    Content type: Research article

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  19. Moringa stenopetala belongs to the flowering family Moringaceae and genus Moringa. It is often referred to as the East African Moringa tree because it is native only to southern Ethiopia and northern Kenya. The e...

    Authors: Alelegne Yeshamebel Adugna, Tileye Feyissa and Fikresilasie Samuel Tasew

    Citation: BMC Biotechnology 2020 20:60

    Content type: Research article

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  20. Equine chorionic gonadotropin (eCG) induces super-ovulation in laboratory animals. Notwithstanding its extensive usage, limited information is available regarding the differences between the in vivo effects of...

    Authors: Kwan-Sik Min, Jong-Ju Park, So-Yun Lee, Munkhzaya Byambaragchaa and Myung-Hwa Kang

    Citation: BMC Biotechnology 2020 20:59

    Content type: Research article

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  21. Development of precise genome editing strategies is a prerequisite for producing edited plants that can aid in the study of gene function and help understand the genetic traits in a cultivar. Citrus embryogeni...

    Authors: Manjul Dutt, Zhonglin Mou, Xudong Zhang, Sameena E. Tanwir and Jude W. Grosser

    Citation: BMC Biotechnology 2020 20:58

    Content type: Research article

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  22. Precise genetic modifications are preferred products of CRISPR-Cas9 mediated gene editing in mammalian cells but require the repair of induced double-strand breaks (DSB) through homology directed repair (HDR)....

    Authors: Sanum Bashir, Tu Dang, Jana Rossius, Johanna Wolf and Ralf Kühn

    Citation: BMC Biotechnology 2020 20:57

    Content type: Research article

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  23. Lignocellulosic biomass, is a great resource for the production of bio-energy and bio-based material since it is largely abundant, inexpensive and renewable. The requirement of new energy sources has led to a ...

    Authors: Shohreh Ariaeenejad, Atefeh Sheykh Abdollahzadeh Mamaghani, Morteza Maleki, Kaveh Kavousi, Mehdi Foroozandeh Shahraki and Ghasem Hosseini Salekdeh

    Citation: BMC Biotechnology 2020 20:56

    Content type: Research article

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  24. Buriti oil presents numerous health benefits, but due to its lipophilic nature and high oxidation, it is impossible to incorporate it into aqueous food matrices. Thus, the present study evaluated whether powde...

    Authors: Gabrielle Mahara Martins Azevedo Castro, Thais Souza Passos, Sara Sayonara da Cruz Nascimento, Isaiane Medeiros, Nathália Kelly Araújo, Bruna Leal Lima Maciel, Carlos Eduardo Padilha, Adriana Margarida Zanbotto Ramalho, Francisco Canidé Sousa Júnior and Cristiane Fernandes de Assis

    Citation: BMC Biotechnology 2020 20:55

    Content type: Research article

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  25. Gene doctoring is an efficient recombination-based genetic engineering approach to mutagenesis of the bacterial chromosome that combines the λ-Red recombination system with a suicide donor plasmid that is clea...

    Authors: Nicholas M. Thomson, Chuanzhen Zhang, Eleftheria Trampari and Mark J. Pallen

    Citation: BMC Biotechnology 2020 20:54

    Content type: Research article

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  26. Few bead-based multiplex assays have been described that detect antibodies against the protozoan parasite Toxoplasma gondii in large-scale seroepidemiological surveys. Moreover, each multiplex assay has specific ...

    Authors: Sandra Klein, Daniel Stern and Frank Seeber

    Citation: BMC Biotechnology 2020 20:53

    Content type: Methodology article

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  27. Obesity and its related diseases are increasing worldwide. One of the best therapeutic strategies for obesity management is through the inhibition of pancreatic lipase (PL) enzyme. So far orlistat is the only ...

    Authors: Sarah Mohamed El-Korany, Omneya Mohamed Helmy, Ali Mahmoud El-Halawany, Yasser El-Mohammadi Ragab and Hamdallah Hafez Zedan

    Citation: BMC Biotechnology 2020 20:52

    Content type: Research article

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  28. Cassava is a staple food for over 800 million people globally providing a cheap source of carbohydrate. However, the cultivation of cassava in the country is facing to viral diseases, particularly cassava mosa...

    Authors: Amitchihoué Franck Sessou, Jane W. Kahia, Jerome Anani Houngue, Elijah Miinda Ateka, Colombe Dadjo and Corneille Ahanhanzo

    Citation: BMC Biotechnology 2020 20:51

    Content type: Research article

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  29. Pelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented use of an aqueous-ethanolic formulation of the roots of P. sidoides (EPs 76...

    Authors: V. Lukman, S. W. Odeyemi, R. L. Roth, L. Mbabala, N. Tshililo, N. M. Vlok, M. J. B. Dewar and C. P. Kenyon

    Citation: BMC Biotechnology 2020 20:50

    Content type: Research article

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  30. Human TGF-β3 has been used in many studies to induce genes coding for typical cartilage matrix components and accelerate chondrogenic differentiation, making it the standard constituent in most cultivation media ...

    Authors: Yijiang Huang, Daniel Seitz, Yan Chevalier, Peter E. Müller, Volkmar Jansson and Roland M. Klar

    Citation: BMC Biotechnology 2020 20:48

    Content type: Research article

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  31. Approximately 40% of prescribed drugs exert their activity via GTP-binding protein-coupled receptors (GPCRs). Once activated, these receptors cause transient changes in the concentration of second messengers, ...

    Authors: Nadine Gruteser, Viktoria Kohlhas, Sabine Balfanz, Arne Franzen, Anne Günther, Andreas Offenhäusser, Frank Müller, Viacheslav Nikolaev, Martin J. Lohse and Arnd Baumann

    Citation: BMC Biotechnology 2020 20:47

    Content type: Methodology article

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  32. Vitrification is the most promising technology for successful cryopreservation of living organisms without ice crystal formation. However, high concentrations (up to ~ 6–8 M) of cryoprotective agents (CPAs) us...

    Authors: Young-Hoon Jeong, Ukjin Kim, Seul-Gi Lee, Bokyeong Ryu, Jin Kim, Artyuhov Igor, Jong Soo Kim, Cho-Rok Jung, Jae-Hak Park and C-Yoon Kim

    Citation: BMC Biotechnology 2020 20:45

    Content type: Research article

    Published on:

  33. Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver. In ...

    Authors: Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi and Yasuhiro Kazuki

    Citation: BMC Biotechnology 2020 20:44

    Content type: Research article

    Published on:

  34. Promoters that confer expression in fruit tissues are important tools for genetic engineering of fruit quality traits, yet few fruit-specific promoters have been identified, particularly for citrus fruit devel...

    Authors: Kasturi Dasgupta, Sara Hotton, William Belknap, Yasra Syed, Christopher Dardick, Roger Thilmony and James G. Thomson

    Citation: BMC Biotechnology 2020 20:43

    Content type: Research article

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  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Noor al Amin, Naveed Ahmad, Nan Wu, Xiumin Pu, Tong Ma, Yeyao Du, Xiaoxue Bo, Nan Wang, Rahat Sharif and Piwu Wang

    Citation: BMC Biotechnology 2020 20:42

    Content type: Correction

    Published on:

    The original article was published in BMC Biotechnology 2019 19:9

  36. The enzyme-linked immunosorbent assay (ELISA), is the most widely used and reliable clinical routine method for the detection of important protein markers in healthcare. Improving ELISAs is crucial for detecti...

    Authors: Tania García-Maceira, Fé I. García-Maceira, José A. González-Reyes and Elier Paz-Rojas

    Citation: BMC Biotechnology 2020 20:41

    Content type: Methodology article

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  37. Xenoantigens are a major source of concern with regard to the success of interspecific xenografts. GGTA1 encodes α1,3-galactosyltransferase, which is essential for the biosynthesis of galactosyl-alpha 1,3-galacto...

    Authors: Fuminori Tanihara, Maki Hirata, Nhien Thi Nguyen, Osamu Sawamoto, Takeshi Kikuchi, Masako Doi and Takeshige Otoi

    Citation: BMC Biotechnology 2020 20:40

    Content type: Research article

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  38. With the high demand for diesel across the world, environmental decontamination from its improper usage, storage and accidental spills becomes necessary. One highly environmentally friendly and cost-effective ...

    Authors: Margaret T. Ho, Michelle S. M. Li, Tim McDowell, Jacqueline MacDonald and Ze-Chun Yuan

    Citation: BMC Biotechnology 2020 20:39

    Content type: Research article

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  39. Inflammatory bowel diseases (IBD) are intestinal disorders characterized by inflammation in the gastrointestinal tract (GIT) and to date, no efficient treatments exist. Interleukin-10 (IL-10), one of the most ...

    Authors: Meritxell Zurita-Turk, Bianca Mendes Souza, Camila Prósperi de Castro, Vanessa Bastos Pereira, Vanessa Pecini da Cunha, Tatiane Melo Preisser, Ana Maria Caetano de Faria, Denise Carmona Cara Machado and Anderson Miyoshi

    Citation: BMC Biotechnology 2020 20:38

    Content type: Research article

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  40. Spider silk is a proteinaceous fiber with remarkable mechanical properties spun from spider silk proteins (spidroins). Engineering spidroins have been successfully produced in a variety of heterologous hosts a...

    Authors: Hui Cai, Gefei Chen, Hairui Yu, Ying Tang, Sidong Xiong and Xingmei Qi

    Citation: BMC Biotechnology 2020 20:37

    Content type: Research article

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  41. Esterases are widely distributed in nature and have important applications in medical, industrial and physiological. Recently, the increased demand for flavor esters has prompted the search of catalysts like l...

    Authors: Xianghai Cai, Lin Lin, Yaling Shen, Wei Wei and Dong-zhi Wei

    Citation: BMC Biotechnology 2020 20:36

    Content type: Research article

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  42. Genome editing is transforming bioscience research, but its application to non-model organisms, such as farmed animal species, requires optimisation. Salmonids are the most important aquaculture species by val...

    Authors: Remi L. Gratacap, Tim Regan, Carola E. Dehler, Samuel A. M. Martin, Pierre Boudinot, Bertrand Collet and Ross D. Houston

    Citation: BMC Biotechnology 2020 20:35

    Content type: Methodology article

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  43. This study reports the analytical sensitivity and specificity of a Loop-mediated isothermal amplification (LAMP) and compares its amplification performance with conventional PCR, nested PCR (nPCR) and real-tim...

    Authors: Phiaw Chong Foo, A. B. Nurul Najian, Nuramin A. Muhamad, Mariana Ahamad, Maizan Mohamed, Chan Yean Yean and Boon Huat Lim

    Citation: BMC Biotechnology 2020 20:34

    Content type: Research article

    Published on:

  44. Helicobacter pylori (H. pylori) infection is a serious human health threat. The empiric H. pylori treatment paradigm guided by traditional testing technologies has led to antibiotic resistance. Here, we improved ...

    Authors: Ling Deng, Xiao-Yi He, Bin Tang, Yang Xiang and Juan-Juan Yue

    Citation: BMC Biotechnology 2020 20:33

    Content type: Methodology article

    Published on:

  45. Immunotoxin is a hybrid protein consisting of a toxin moiety that is linked to a targeting moiety for the purpose of specific elimination of target cells. Toxins used in traditional immunotoxins are practicall...

    Authors: William F. Jiemy, Lih Fhung Hiew, Hong Xi Sha, Lionel L. A. In and Jung Shan Hwang

    Citation: BMC Biotechnology 2020 20:31

    Content type: Research article

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