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Microbial biotechnology

This section will consider studies that focus on the genetic manipulation and synthetic/systems biology of bacteria, fungi, yeasts and algae in the context of bioproduction, fermentation, metabolic engineering, biocatalysis, bioremediation and biodegradation.

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  1. Plasmid-based overexpression of genes has been the principal strategy for metabolic engineering. However, for biotechnological applications, plasmid-based expression systems are not suitable because of genetic...

    Authors: Yun-Yan Chen, Hong-Jie Shen, Yan-Yan Cui, Shang-Guang Chen, Zhi-Ming Weng, Ming Zhao and Jian-Zhong Liu

    Citation: BMC Biotechnology 2013 13:6

    Content type: Research article

    Published on:

  2. Halorubrum lacusprofundi is a cold-adapted halophilic archaeon isolated from Deep Lake, a perennially cold and hypersaline lake in Antarctica. Its genome sequencing project was recently completed, providing acces...

    Authors: Ram Karan, Melinda D Capes, Priya DasSarma and Shiladitya DasSarma

    Citation: BMC Biotechnology 2013 13:3

    Content type: Research article

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  3. Yeast Saccharomyces cerevisiae is a widely-used system for protein expression. We previously showed that heat-killed whole recombinant yeast vaccine expressing mammalian myostatin can modulate myostatin function ...

    Authors: Tingting Zhang, Lin Sun, Ying Xin, Lixia Ma, Youyou Zhang, Xin Wang, Kun Xu, Chonghua Ren, Cunfang Zhang, Zhilong Chen, Hanjiang Yang and Zhiying Zhang

    Citation: BMC Biotechnology 2012 12:97

    Content type: Research article

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  4. Currently, the two most commonly used fibrinolytic agents in thrombolytic therapy are recombinant tissue plasminogen activator (rt-PA) and streptokinase (SK). Whereas SK has the advantage of substantially lowe...

    Authors: Manal Moussa, Mahmoud Ibrahim, Maria El Ghazaly, Jan Rohde, Stefan Gnoth, Andreas Anton, Frank Kensy and Frank Mueller

    Citation: BMC Biotechnology 2012 12:96

    Content type: Research article

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  6. Biliverdin IXα is produced when heme undergoes reductive ring cleavage at the α-methene bridge catalyzed by heme oxygenase. It is subsequently reduced by biliverdin reductase to bilirubin IXα which is a potent...

    Authors: Dong Chen, Jason D Brown, Yukie Kawasaki, Jerry Bommer and Jon Y Takemoto

    Citation: BMC Biotechnology 2012 12:89

    Content type: Research article

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  7. The ketoisovalerate reductase (EC 1.2.7.7 ) is required for the formation of beauvericin via the nonribosomal peptide synthetase biosynthetic pathway. It catalyzes the NADPH-specific reduction of ketoisovaleri...

    Authors: Tao Zhang, XiaoPeng Jia, Ying Zhuo, Mei Liu, Hong Gao, JinTao Liu and Lixin Zhang

    Citation: BMC Biotechnology 2012 12:55

    Content type: Research article

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  8. The ability to produce the same recombinant protein in both prokaryotic and eukaryotic cells offers many experimental opportunities. However, the cloning of the same gene into multiple plasmids is required, wh...

    Authors: Namita Sinah, Charlotte A Williams, Robert C Piper and S Brookhart Shields

    Citation: BMC Biotechnology 2012 12:54

    Content type: Research article

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  9. Pseudomonas putida KT2440 is able to synthesize large amounts of medium-chain-length polyhydroxyalkanoates (mcl-PHAs). To reduce the substrate cost, which represents nearly 50% of the total PHA production cost, x...

    Authors: Sylvaine Le Meur, Manfred Zinn, Thomas Egli, Linda Thöny-Meyer and Qun Ren

    Citation: BMC Biotechnology 2012 12:53

    Content type: Research article

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  10. The otrC gene of Streptomyces rimosus was previously annotated as an oxytetracycline (OTC) resistance protein. However, the amino acid sequence analysis of OtrC shows that it is a putative ATP-binding cassette (A...

    Authors: Lan Yu, Xiangyun Yan, Long Wang, Ju Chu, Yingping Zhuang, Siliang Zhang and Meijin Guo

    Citation: BMC Biotechnology 2012 12:52

    Content type: Research article

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  11. Food industries aim to replace trans fat in their products by formulations having equivalent functionality and economic viability. Enzymatic transesterification can be a technological option to produce trans f...

    Authors: Mohamed Sellami, Hanen Ghamgui, Fakher Frikha, Youssef Gargouri and Nabil Miled

    Citation: BMC Biotechnology 2012 12:48

    Content type: Research article

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  12. Baeyer-Villiger monooxygenases (BVMOs) represent a group of enzymes of considerable biotechnological relevance as illustrated by their growing use as biocatalyst in a variety of synthetic applications. However...

    Authors: Edwin van Bloois, Hanna M Dudek, Wouter A Duetz and Marco W Fraaije

    Citation: BMC Biotechnology 2012 12:31

    Content type: Research article

    Published on:

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