Table 4 The validated candidate drugs by CMAP analysis

PACLITAXEL

4

ARL4D, NUP214, LARP7, NEK9, C20ORF27, TOR1AIP1

POLA1, CCNE1, BSG, FKBP10, GTF2F2, HMOX1

DAUNORUBICIN

3

PCM1, NLRX1, C20ORF27, HMOX1

PLEKHF2, TIMM9, PRIM1, CLIP4

VORINOSTAT

3

SLC9A3R1, ATP6V1A, KDELC1, NEU1, ARL4D, ERO1LB, PDE4DIP

CCND1, H2AFY2, ZC3H7A, CDKN1B, USP13, MEPCE

DOXORUBICIN

2

FKBP10, TPSB2, ARL4D

PLEKHF2, DNAJB1

DEXAMETHASONE

2

GSK3A, BRF1, C20ORF27, NUP214, HOOK1, POR

FKBP10, NLRX1, TRIM25, LCP1, HMOX1, RALA, SLC46A3, NPTX1

IRINOTECAN

2

BRD2, NGDN

GSK3B, TIAM1

DIETHYLSTILBESTROL

2

ERO1LB, CEACAM5, ALB, INHBE, CLIP4

FOXRED2, PLOD2, POLA1, PLD3, NOL10

DECITABINE

2

ERP44,

FKBP10,

IFOSFAMIDE

2

NEK9, RAB2A, LOX,

FKBP10, RCAN3,

SIROLIMUS

2

G3BP1, DIDO1, AKAP8L, SUN2, DDAH2, CEACAM5, CEP68, SIGMAR1, NUP88, PDE4DIP, ITGB1, NOL10, POFUT1, NLRX1, FKBP10, F2RL1, ERP44, COL6A1, IFIH1, BRF1, TAPT1, IKBKB, SCARB1, DPY19L1, SMAD3, LOX, SIRT5, CHPF, NEK9, SMAD3, HMOX1, ERMP1, POFUT1, PDE4DIP, PRIM2,

CCNE1, FOXRED2, SUN2, CHEK2, POR, CHPF, RALA, GOLGA3, FKBP10, DDX58, PRKAR2B, TIMM9, CCDC86, SGTA, TRIM25, NMB, FASTKD5, ERO1LB, STC2, VPS11, HMOX1, DDX10, NOL10, RRP9, SIL1,

PROCAINE

2

G3BP1, NUP88, MASP2

SLC46A3, SLC9A3R1, PLD3