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Fig. 4 | BMC Biotechnology

Fig. 4

From: Comparative gene expression profiling of mouse ovaries upon stimulation with natural equine chorionic gonadotropin (N-eCG) and tethered recombinant-eCG (R-eCG)

Fig. 4

Hierarchical clustering of gene expression profiles in N-eCG-treated and R-eCG-treated ovarian tissues. The ovaries were excised from 8-week-old ICR female mice. The mice were induced to superovulate with 10 IU of N-eCG or R-eCG and then 10 IU of hCG after 48 h, and the ovulated oocytes were collected in an oviduct ampulla after 13 h. Thereafter, the ovaries were harvested after 13 h and RNA was analyzed via microarray analysis. Gene expression levels were evaluated through microarray analysis with 12,816 gene probes. Genes showing > 2-fold differences in expression were identified. The expression of 63 (0.49%) of 12,816 genes differed by at least 2-fold between N-eCG-treated and R-eCG-treated ovaries. Twenty of 63 genes were up-regulated in R-eCG-treated ovaries and 43 genes were down-regulated

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