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Table 1 IC50 of CD64 targeted recombinant immunotoxins

From: Evaluation of Hydra HALT-1 as a toxin moiety for recombinant immunotoxin

Recombinant immunotoxin

Cell line

IC50 (nM)

References

H22(scFv)-ETA

HL60

0.17

[26]

H22(scFv)-ETA

U937

0.14

[25]

H22(scFv)2-ETA

U937

0.014

[25]

granzymeB-H22(scFv)

U937

1.7–17

[40]

H22(scFv)-MAP

HL60

0.04

[27]

HALT-1-scFv

THP-1

189

This study

HALT-1-scFv

HeLa

339.96

This study

scFv-HALT-1

THP-1

196.64

This study

scFv-HALT-1

HeLa

371.54

This study