Enhanced Natamycin production by Streptomyces natalensis in shake-flasks and stirred tank bioreactor under batch and fed-batch conditions

Table 1 Kinetic parameters of cell growth and natamycin production by S. natalensis NRRL 2651 as affected by initial glucose concentration

Concentration (g/L)	X_max (g/L)	P_max (g/L)	ΔS (%)	Q_x^a (g/L/h)	Q_p^a (g/L/h)	Q_s^a (g/L/h)	Y_x/s (g/g)	Y_p/s (g/g)	Y_p/x (g/g)
10	3.26 ± 0.13	0.35 ± 0.04	100	0.075	0.011	- 0.22	0.35	0.038	0.121
20	4.78 ± 0.13	1.58 ± 0.03	100	0.099	0.021	- 0.41	0.28	0.083	0.332
30	5.66 ± 0.14	0.82 ± 0.03	85.8	0.11	0.013	- 0.39	0.39	0.044	0.185
40	5.59 ± 0.23	0.43 ± 0.02	72	0.12	0.006	- 0.38	0.31	0.027	0.122
50	5.66 ± 0.19	0.43 ± 0.07	70	0.14	0.006	- 0.50	0.31	0.015	0.102

X_max: maximal cell dry weight; P_max: maximal natamycin production; ΔS: % consumed glucose; Q_X: average cell growth rate; Q_P: average natamycin production rate; Q_S: average glucose consumption rate; Y_X/S: maximal yield of biomass per consumed glucose; Y_P/S: maximal yield of natamycin per consumed glucose; Y_P/X: maximal yield of natamycin per biomass. ^a Data are calculated at the end of the exponential growth phase

ISSN: 1472-6750