Genome-wide response on phytosterol in 9-hydroxyandrostenedione-producing strain of Mycobacterium sp. VKM Ac-1817D

Bragin, Eugeny Y.; Shtratnikova, Victoria Y.; Schelkunov, Mikhail I.; Dovbnya, Dmitry V.; Donova, Marina V.

doi:10.1186/s12896-019-0533-7

Table 2 Phytosterol inducible expression changes of known sterol catabolism genes

From: Genome-wide response on phytosterol in 9-hydroxyandrostenedione-producing strain of Mycobacterium sp. VKM Ac-1817D

Gene name	Locus	Expression increasing	Function of ortholog	References
ltp3	G155_04795	96.89	Aldol lyase	[17]
ltp4	G155_04800	96.38	Aldol lyase	[17]
echA19	G155_04835	68.59	Enoyl-CoA hydratase	[2]
fadD19	G155_04840	97.53	Long-chain fatty-acid-CoA ligase	[47]
fadD17	G155_04880	81.64	Long-chain fatty-acid-CoA ligase	[18]
chsE5(fadE27)	G155_04885	74.14	Acyl-CoA dehydrogenase	[48]
chsE4(fadE26)	G155_04890	89.21	Acyl-CoA dehydrogenase	[48]
ltp2	G155_26150	69.08	Putative thiolase	[49]
chsH1	G155_26155	66.32	Steroid enoyl-CoA hydratase	[50]
chsH2	G155_26160	62.40	Steroid enoyl-CoA hydratase	[50]
chsE2(fadE29)	G155_26165	76.45	Acyl-CoA dehydrogenase	[20]
chsE1(fadE28)	G155_26170	58.19	Acyl-CoA dehydrogenase	[20]
cyp125	G155_26175	107.58	C26-steroid monooxygenase	[14]
fadA5	G155_26180	136.07	Acetyl-CoA acetyltransferase	[19]
chsE3(fadE34)	G155_26510	50.22	Acyl-CoA dehydrogenase	[51]
kstD	G155_04625	61.43	3-oxosteroid 1-dehydrogenase	[52]
4kstD	G155_08770	10.09	3-oxosteroid 1-dehydrogenase	[53]
hsaE	G155_04630	11.57	2-keto-4-pentenoate hydratase	[25]
hsaG	G155_04635	9.95	Acetaldehyde dehydrogenase	[25]
hsaF	G155_04640	7.13	4-hydroxy-2-oxovalerate aldolase	[25]
kshA_1	G155_04755	55.51	3-ketosteroid-9-alpha-hydroxylase oxygenase subunit	[21]
kshA_2	G155_24375	24.58	3-ketosteroid-9-alpha-hydroxylase oxygenase subunit	[21]
hsaB	G155_26470	26.88	Monooxygenase component B	[26]
hsaC	G155_26475	26.18	2,3-dihydroxybiphenyl 1,2-dioxygenase
hsaD	G155_26480	32.34	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	[27]
hsaA	G155_26485	34.01	Monooxygenase component A	[26]
kshB	G155_26490	39.90	3-ketosteroid-9-alpha-hydroxylase reductase subunit	[21]
hsd	G155_22700	83.36	3-hydroxysteroid dehydrogenase	[54]
Hsd4A	G155_04900	11.12	17β- hydroxysteroid dehydrogenase	[55]
echA20	G155_26220	9.82	Putative enoyl-CoA hydratase	[38]
ipdA	G155_26225	8.61	Putative CoA-transferase subunit alpha	[38]
ipdB	G155_26230	8.35	Putative CoA-transferase subunit beta	[38]
fadA6	G155_26270	16.55	3-ketoacyl-CoA thiolase, acetyl-CoA acetyltransferase	[38]
fadE30	G155_26335	10.49	Acyl-CoA dehydrogenase	[38]
fadD3	G155_26340	9.84	Fatty-acid-CoA ligase	[38]
fadE31	G155_26345	8.60	Acyl-CoA dehydrogenase	[38]
fadE32	G155_26350	7.51	Acyl-CoA dehydrogenase	[38]
fadE33	G155_26355	8.45	Acyl-CoA dehydrogenase	[38]
kstR	G155_26515	13.17	Transcriptional regulator, TetR family	[28]
kstR2	G155_26275	15.81	Transcriptional regulator, TetR family	[36]
yrbEA	G155_04905	3.58	Conserved hypothetical integral membrane protein	[56]
yrbEB	G155_04910	3.71	Conserved hypothetical integral membrane protein	[56]
mceA	G155_04915	3.21	MCE-family protein	[56]
mceB	G155_04920	3.63	MCE-family protein	[56]
mceC	G155_04925	3.67	MCE-family protein	[56]
mceD	G155_04930	3.40	MCE-family protein	[56]
mceE	G155_04935	3.87	MCE-family protein	[56]
mceF	G155_04940	3.17	MCE-family protein	[56]
mas4B	G155_04950	3.07	MCE-associated protein	[56]

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