Treatment | SD100 | SD100 Δslr2131 | SD100 Δslr2131 pacrB | SD100 Δsll0180 | SD100 Δsll0180 pSacrA | |
Amp | IC50 | 955.2 ± 256 μg/mL | 1280 ± 230 μg/mL (ns) | 891 ± 117 μg/mL (ns) | 598 ± 296 μg/mL | 577.0 ± 23.2 μg/mL |
% diff from SD100 | 0% | 34% | −6.7% | 37% | 39% | |
Cm | IC50 | 2.290 ± 0.401 μg/mL | 0.586 ± 0.142 μg/mL | 2.124 ± 1.004 μg/mL (ns) | 1.442 ± 0.206 μg/mL | 4.73 ± 1.47 μg/mL |
% diff from SD100 | 0% | −74% | −7.2% | −37% | 106% | |
Ery | IC50 | 0.358 ± 0.081 μg/mL | 0.054 ± 0.002 μg/mL | 0.103 ± 0.019 μg/mL | 0.172 ± 0.1 μg/mL | 0.144 ± .028 μg/mL |
% diff from SD100 | 0% | −85% | −71% | −52% | −60% | |
Treatment | SD277 | SD277 Δslr2131 | SD277 Δslr2131 pacrB | SD277 Δsll0180 | SD277 Δsll0180 pSacrA | |
Amp | IC50 | 1570 ± 170 μg/mL | 1001 ± 120 μg/mL | 980.3 ± 37 μg/mL | 450 ± 119 μg/mL | 286.6 ± 113.8 μg/mL |
% diff from SD277 | 0% | −36% | −38% | −71% | −82% | |
Cm | IC50 | 4.749 ± 1.043 μg/mL | 1.873 ± 0.354 μg/mL | 3.305 ± 1.100 μg/mL (ns) | 1.085 ± 0.589 μg/mL | 3.486 ± 1.027 μg/mL (ns) |
% diff from SD277 | 0% | −61% | −30% | −77% | −27% | |
Ery | IC50 | 0.427 ± 0.249 μg/mL | 0.171 ± 0.044 μg/mL | 0.095 ± 0.007 μg/mL | 0.034 ± 0.007 μg/mL | 0.075 ± 0.014 μg/mL |
% diff from SD277 | 0% | −60% | −78% | −92% | −82% |