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Table 1 A comparison of different nomenclature systems for ABC proteins

From: Diversity of ABC transporter genes across the plant kingdom and their potential utility in biotechnology

HUGO subfamily

Sánchez-Fernández subfamilya

ABCISSE familyb,c

ABCISSE subfamilyb,c

TC subfamilyd

Domain organization

Taxa

ABCA

ABC1 homologue (AOH)

Drug and antibiotic resistance (DRA)

ABCA

Cholesterol/phospholipid/retinal flippase (CPR)

(TMD-NBD)2

eukaryotes (not yeast)

ABC2 homologue (ATH)

TMD-NBD

eukaryotes

ABCB

Multidrug resistance (MDR)

Drug, peptides and lipid export (DPL)

p-glycoprotein (p-GP)

MDR

(TMD-NBD)2

prokaryotes and eukaryotes

Transporter associated with antigen processing (TAP)

TAP and multidrug resistance-like protein (MDL)

TAP and mitochondrial peptide exporter (MPE)

TMD-NBD

eukaryotes

ABC transporter of the mitochondria (ATM)

Heavy metal tolerance (HMT)

HMT

TMD-NBD

eukaryotes

-

Lipid A-like exporter, putative (LLP)

-

TMD-NBD

prokaryotes and plants

ABCC

Multidrug resistance associated protein (MRP)

Organic anion conjugates and drug export (OAD)

MRP

Conjugate transporter (CT)

(TMD-NBD)2

eukaryotes

ABCD

Peroxisomal membrane protein (PMP)

Fatty acid export (FAE)

-

Peroxisomal fatty acyl-CoA transporter (P-FAT)

TMD-NBD; (TMD-NBD)2

bacteria and eukaryotes

ABCE

RNase L inhibitor (RLI)

RNase L inhibitor (RLI)

-

-

NBD-NBD

archaea and eukaryotes

ABCF

General control non-repressible (GCN)

Antibiotic resistance and translation regulation (ART)

Gene expression regulation (REG)

-

NBD-NBD

bacteria and eukaryotes

ABCG

White-brown complex homologue (WBC)

Eye pigment precursors and drugs (EPD)

WHITE

Eye pigment precursor transporter (EPP)

NBD-TMD

bacteria and eukaryotes

Pleiotropic drug resistance (PDR)

PDR

PDR

(NBD-TMD)2

plants and fungi

ABCH

-

Drug resistance, bacteriocin and lantibiotic immunity (DRI)

YHIH

 

NBD-TMD

prokaryotes, slime moulds, echinoderms, insects and fish

  1. References: a[8], b[6], c[4], d[52], Figure reprinted from [5] with permission