Figure 4

RNA-seq coverage profiles across introns of different sizes. The average RNA-seq coverage was computed for all different RNA-seq fractions of Sample 1 and the polyA+ RNA sample acquired from Clontech, by dividing each intron into 100 bins. The regions flanking the introns (to the left and right of the dotted lines, respectively) show the average coverage in 50 bp regions upstream and downstream of the introns. The panels show the average coverage profiles for A) all 1567 ‘XL’ introns of size at least 100 kb. B) 2792 ‘L’ introns of size 50–100 kb. C) 19996 ‘M’ introns of size 10–50 kb D) 98636 ‘S’ introns of size 1–10 kb.